Prediction: Giants 27, Chargers 17The Giants will face the Denver Broncos for just the 12th time in the regular season dating back to 1972.
Up first for the Giants at home will be the Detroit Lions, who roll into Met Life Stadium for a Monday night game.
They need to address their running game, which finished 24th last year (five spots ahead of the Giants), averaging 101 yards per game.
Doug Martin, who was supposed to be their bell cow, will miss the first three games of 2017 as he completes a four-game league-imposed suspension handed down last December that was related to violating the league's drug use policy.
In addition to five of the team's eight road games being west of the Mississippi, the Giants will face four of the six teams who hired new head coaches for 2017: Rams (Sean Mc Vay), Chargers (Anthony Lynn), 49ers (Kyle Shanahan) and Broncos (Vance Joseph).
For the third straight year, the Giants will open the regular-season campaign on the road against the Dallas Cowboys.